FIG 2.

Percent survival of mice in a model of influenza virus infection following prophylactic or therapeutic administration of D1-8. (A) BALB/c mice were treated with D1-8 at the indicated concentrations or with a control MAb and then infected with rHK68 4 h later. Percent survival versus time is presented. (B) BALB/c mice were infected with rHK68 and treated with D1-8 (30 mg/kg) 4 h (D0) or 1 (D1), 2 (D2), 3(D3), or 4 (D4) days after infection. Control mice were treated with an irrelevant control (Ctrl) MAb 4 h prior to infection. Percent survival versus time is presented. (C) Mice were infected as described for panel B and sacrificed 4 days after infection, and virus titers in lungs were measured using the TCID₅₀ method. **, P < 0.01 versus value for control mice (Mann-Whitney test).