FIG 3.

Therapeutic efficacy of D1-8 compared to oseltamivir in an influenza virus mouse model late in infection. Mice received a single intraperitoneal injection of D1-8 (2.5 mg/kg) 4 days after infection or 25 mg/kg of oseltamivir, given orally twice a day (50 mg/kg/day) for 5 days, with dosing initiated 4 days after infection. Mice were monitored for 14 days for body weight loss (A) and survival (B). Mean change in body weight is expressed as a percentage of the baseline body weight. Error bars represent 95% confidence intervals.