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Susceptibilities of rWY03 variants to D1-8 neutralization or HAI
| H3 variant | IC50 (μg/ml) |
Fold change relative to rWY03 |
||
|---|---|---|---|---|
| HAI | Neutralization | HAI | Neutralization | |
| rWY03 (wild type) | 0.55 | 0.017 | 1 | 1 |
| rWY03_N171K | >1,200 | >1,200 | >2,181 | >70,000 |
| rWY03_N171E | >1,200 | >1,200 | >2,181 | >70,000 |
| rWY03_N171D | >1,200 | >1,200 | >2,181 | >70,000 |
| rWY03_E172G | 29 | 4.49 | 53 | 264 |
| rWY03_K173T | >1,200 | >1,200 | >2,181 | >70,000 |
| rWY03_K207N | 1.65 | 1.54 | 3 | 59 |
| rWY03_G240E | 44 | 14.51 | 80 | 854 |
| rWY03_E172G/K207N | >1,200 | >1,200 | >2,181 | >70,000 |
