FIG 4.

Viremia and neutralizing antibody titers following challenge with DENV-1 (DV1). (A) HR-Tet animals challenged with DV1 HI had on average 1 log less viremia following challenge compared to mock-vaccinated animals challenged with the same dose of DV1 HI. A significant difference in viremia between the groups was noted on days 2, 3, 6, and 9 (P < 0.02). Graphed titers are averages from four animals challenged with DV1 HI. (B) There was also a large difference in neutralizing antibody titer in mock-vaccinated animals compared to HR-Tet animals following challenge. All animals given HR-TET had high neutralizing antibody titers following challenge with DV1 HI. However, only 25% of mock-vaccinated animals developed neutralizing antibody titers following challenge with DV1 HI.