FIG 6.

Viremia and neutralizing antibody titers following challenge with DENV-3 (DV3). (A) HR-Tet animals challenged with DV3 H87 had viremia on average 1 log lower in titer following challenge than mock-vaccinated animals challenged with the same dose of DV3 H87. A significant difference in titer between the two groups was noted on days 2, 3, 5, 6, and 9 (P < 0.02). Graphed titers are averages from four animals challenged with DV3 H87. (B) There was also a difference in neutralizing antibody titer in mock-vaccinated animals compared to HR-Tet animals following challenge. Animals given HR-Tet prior to challenge had much faster, stronger, and more-sustained neutralizing antibody production than did mock-vaccinated animals challenged with DV3 H87.