FIG 7.

Viremia and neutralizing antibody postchallenge with DENV-4 (DV4). (A) HR-Tet animals challenged with DV4 H241 had lower viremia, which was cleared more quickly, than mock-vaccinated animals challenged with the same dose of DV4 H241. A significant difference in titers between the two groups was noted on days 3, 4, and 5 (P < 0.02). Graphed titers are averages from four animals challenged with DV4 H241. (B) There was also a difference in neutralizing antibody titers in mock-vaccinated animals compared to HR-Tet animals following challenge. Animals given HR-Tet prior to challenge had much faster, stronger, and more-sustained neutralizing antibody production than mock-vaccinated animals challenged with DV4 H241.