FIG 1.
Amino acid sequences of F005-126 VH and VL. (A) Amino acid numbers are according to the Kabat numbering system. Framework regions FR1, FR2, FR3, and FR4 and complementary determining regions CDR1, CDR2, and CDR3 are shown. Comparison of amino acid sequences of VHs and VLs to germ line sequences was performed according to IgBLAST (http://www.ncbi.nlm.nih.gov/igblast/). Amino acid sequence identities (%) of MAbs with germ line VH or VL are shown. From X-ray analysis, amino acid sequences indicated in orange, green, and red were bound to site L, site R, and a glycan at HA-R:Asn285, respectively. (B) Predicted deletion of DH and JH genes and insertion of N segments are shown. The nucleotide sequence GTTCGGGGAGTT, encoding the 4-amino-acid sequence V98–R99-G100–V100a in F005-126–HCDR3, is indicated in pink.