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Overall backbone structures of the coevolved and mutant complexes are similar to that of PRWT–p1-p6WT. (A) Superposition of the WT and D30N/N88D PRs in complex with p1-p6 variants. (B) Superposition of the p1-p6 peptide in the active site of the PR variants. Note the different orientations of the Gag452 side chain. (C) The different p1-p6 peptides used in this study with their Gag numbering as well as the peptide site numbering.
