TABLE 1.

Variation in the frequency of reassortant progeny over time after infection

Guinea pig no.	Inoculum dose (PFU)a	Genotypes of virus isolates (%)b
		Day 1			Day 2			Day 3			Day 6
		R	wt	var	R	wt	var	R	wt	var	R	wt	var
1	2 × 102	ND	ND	ND	0	100	0	0	100	0	0	100	0
2	2 × 102	ND	ND	ND	5	0	95	5	0	95	5	0	95
3	2 × 102	ND	ND	ND	0	100	0	0	100	0	0	100	0
4	2 × 102	ND	ND	ND	0	100	0	0	100	0	0	100	0
5	2 × 102	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND
6	2 × 103	0	5	95	5	20	75	38	33	29	5	90	5
7	2 × 103	0	29	71	0	5	95	28	24	48	0	14	86
8	2 × 103	0	81	19	24	43	33	5	0	95	5	0	95
9	2 × 103	5	10	85	10	40	50	57	33	10	35	65	0
10	2 × 103	0	0	100	0	5	95	24	71	5	24	38	38
11	2 × 106	48	33	19	67	14	19	63	37	0	ND	ND	ND
12	2 × 106	57	43	0	50	15	35	67	33	0	ND	ND	ND
13	2 × 106	63	32	5	65	35	0	45	35	20	ND	ND	ND
14	2 × 106	62	33	5	70	20	10	74	16	10	ND	ND	ND
15	2 × 106	65	25	10	61	17	22	78	17	5	ND	ND	ND

^aInocula contained 50% wt and 50% var viruses (n = 36). The total dose for wt + var is indicated.

^bn = 18 to 21. R, any reassortant genotype. ND, virus was not detected in nasal washings at these time points (limit of detection = 50 PFU/ml).