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. 2014 Jul;88(13):7485–7492. doi: 10.1128/JVI.00715-14

TABLE 3.

Relative inoculation doses of wt and var viruses impact which genotypes emerge following coinfectiona

Ratio (wt/var), inoculum (PFU) No. of var parental/total parental isolatesb (P = 0.0026) No. of var segments/total segments in reassortant isolatesc (P = 0.0005)
1:12.5, 1 × 105 0.89 0.50
1.00 0.84
1.00 0.63
0.85 0.66
0.67 0.67
    Avg 0.88 0.66
1:7, 2 × 106 0.89 0.68
1.00 0.76
1.00 0.68
1.00 0.63
1.00 0.78
    Avg 0.98 0.71
1:1, 2 × 106 0.57 0.43
0.70 0.56
0.00 0.52
0.33 0.48
0.57 0.46
    Avg 0.44 0.49
a

Data are derived from day 2 nasal washes of guinea pigs 11 to 15 shown in Fig. 2 (1:1 group) and the guinea pigs shown in Fig. 3. A Student t test was used to compare guinea pigs inoculated with 1:1 and 1:7 mixtures at the 2 × 106 PFU dose. The P values are indicated in the respective column headings.

b

The number of var parental isolates, divided by the sum of wt + var parental isolates, is shown.

c

The number of var gene segments included in reassortant genomes, divided by the sum of wt + var gene segments in reassortant genomes, is shown.