TABLE 3.
Ratio (wt/var), inoculum (PFU) | No. of var parental/total parental isolatesb (P = 0.0026) | No. of var segments/total segments in reassortant isolatesc (P = 0.0005) |
---|---|---|
1:12.5, 1 × 105 | 0.89 | 0.50 |
1.00 | 0.84 | |
1.00 | 0.63 | |
0.85 | 0.66 | |
0.67 | 0.67 | |
Avg | 0.88 | 0.66 |
1:7, 2 × 106 | 0.89 | 0.68 |
1.00 | 0.76 | |
1.00 | 0.68 | |
1.00 | 0.63 | |
1.00 | 0.78 | |
Avg | 0.98 | 0.71 |
1:1, 2 × 106 | 0.57 | 0.43 |
0.70 | 0.56 | |
0.00 | 0.52 | |
0.33 | 0.48 | |
0.57 | 0.46 | |
Avg | 0.44 | 0.49 |
Data are derived from day 2 nasal washes of guinea pigs 11 to 15 shown in Fig. 2 (1:1 group) and the guinea pigs shown in Fig. 3. A Student t test was used to compare guinea pigs inoculated with 1:1 and 1:7 mixtures at the 2 × 106 PFU dose. The P values are indicated in the respective column headings.
The number of var parental isolates, divided by the sum of wt + var parental isolates, is shown.
The number of var gene segments included in reassortant genomes, divided by the sum of wt + var gene segments in reassortant genomes, is shown.