Figure 2.

RNA splicing map of multivalent RNA motifs enriched at NOVA target exons. Sequences of the enriched tetramers are shown on the left, followed by a color-coded panel showing the regions where tetramer enrichment reached the defined threshold around silenced (blue) or enhanced (red) exons. The gray panel marks the tetramers that overlap in their sequence (marked in the same shade of grey), and the right panel depicts the nucleotide-resolution RNA splicing map of each motif at the enhanced or silenced exons, and their flanking exons. The color key indicates whether the position-specific contribution originates from enhanced (E; red), silenced (S; blue), or both (yellow) sets. The maximum enrichment score (ES) value of the top tetramer, which is used to plot all tetramers, is reported on the right. Nt, nucleotides.