Figure 6.
RNA splicing maps of multivalent RNA motifs enriched at the exons differentially spliced between adult brain and heart. The RNA splicing maps are shown as described in Figure 2 for a comparison between adult brain and heart splicing. (A) Tetramers enriched at positions corresponding to the standard pattern of RNA maps (enrichment in r1 and r2 of exons silenced in the brain, and/or in r3 of exons enhanced in the brain). These tetramers are predicted to be bound by RBPs with higher expression in the brain compared with the heart. (B) The 10 top ranking tetramers enriched at positions corresponding to the reciprocal pattern of RNA maps (enrichment in r1 and r2 of exons enhanced in the brain, and/or in r3 of exons silenced in the brain). These tetramers are predicted to be bound by RBPs with higher expression in the heart compared to the brain. Nt, nucleotides.