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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: J Hepatol. 2013 Aug 23;60(1):160–166. doi: 10.1016/j.jhep.2013.08.015

Fig. 4. Effect of oltipraz on hepatic expression of genes involved in fibrosis and tissue remodeling.

Fig. 4

Relative mRNA expression of (A) MMP2, (B) MMP9, (C) MMP13, (D) TIMP-1, and (E) TIMP-2 in livers of unoperated and BDL mice treated with CMC or oltipraz. All five genes were significantly increased by the bile duct ligation and, in addition, MMP9, MMP13, TIMP-1 and TIMP-2 mRNA levels were further increased after treatment with oltipraz. (F) Livers from oltipraz treated BDL mice exhibited decreased hepatic collagen deposition as determined by relative hydroxyproline content. * p < 0.05; between indicated groups.