Figure 1.

Evidence network for all-cause stroke or systemic embolism. (Four RCTs, PETRO,²⁴ WASPO²⁵ Chung et al²⁶ and Yamashita et al,²⁷ were not included in the analysis because they did not report data for this outcome or had zeros in both arms.) The width of the lines is proportional to the number of randomised controlled trials comparing each pair of treatments, and the size of each treatment node is proportional to the number of randomised participants (sample size). A dotted line indicates a three-arm randomised controlled trial and a black node indicates a node included in the analysis but not reported in the main text. ASA, acetylsalicylic acid; RCT, randomised controlled trial; VKA, vitamin K antagonist.