Table 1.
The levels of Aβ in the brains of mice of each genotype and age
| Age (month) | Cre | N | Aβ40 (pg/mg brain) | Aβ42 (pg/mg brain) | ratio 40/42 | ||||
|---|---|---|---|---|---|---|---|---|---|
| Average | STDEV.P | P-value | Average | STDEV.P | P-value | ||||
| 8 | - | 3 | 1,257 | 1,022 | 0.40 | 271 | 193 | 0.45 | 4.6 |
| + | 3 | 481 | 315 | 142 | 75 | 3.4 | |||
| 9 | - | 17 | 2,024 | 1,192 | 0.90 | 399 | 192 | 0.71 | 5.1 |
| + | 12 | 2,074 | 746 | 421 | 116 | 4.9 | |||
| 15 | - | 4 | 4,235 | 946 | 0.65 | 1,015 | 104 | 0.74 | 4.2 |
| + | 4 | 4,582 | 823 | 972 | 188 | 4.7 | |||
| 16 to 18 | - | 4 | 4,445 | 1,135 | 0.74 | 971 | 181 | 0.79 | 4.6 |
| + | 5 | 4,830 | 1,777 | 1,020 | 289 | 4.7 | |||
There was no difference in the levels of Aβ40 and 42 in the brains of mouse expressing APPswe/PS1dE9 gene in the LRP1 lox/lox homozygous background in the absence or presence of the GFAP-Cre transgene in any given age group.