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Phosphorylation of BCL2 at multiple sites by c Jun N terminal protein kinase 1 (JNK1) and extracellular signal related kinase (ERK) have been shown to reduce binding of BCL2 to Beclin 1, leading to the activation of autophagy However, once released from BCL2, as shown in figure 2, translocation of C terminal fragment of BECN1 to the outer mitochondrial membrane can induce cytochrome-c release and apoptosis.
