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. Author manuscript; available in PMC: 2015 May 22.
Published in final edited form as: Cell. 2014 May 22;157(5):1117–1129. doi: 10.1016/j.cell.2014.03.053

Figure 1. High-resolution cryo-EM structures of dynamic and stabilized microtubules.

Figure 1

A) Cartoon of the αβ–tubulin dimer, which spontaneously exchanges bound GDP for GTP in solution. B) Cartoon illustrating structural intermediates of microtubule polymerization and depolymerization. C) Cryo-EM maps of GMPCPP (left panel, 4.7 Å resolution), GDP (middle panel, 4.9 Å resolution) and taxol-stabilized (right panel, 5.6 Å resolution) microtubules, viewed from inside the microtubule lumen. α-tubulin, green, β-tubulin, blue, GMPCPP/GTP, orange, GDP, pink, taxol, yellow. Maps are contoured at 1.1 σ. (See also Table S1a, Figures S1 and S2 and Movies S1, S2 and S3)