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. Author manuscript; available in PMC: 2015 May 22.
Published in final edited form as: Cell. 2014 May 22;157(5):1117–1129. doi: 10.1016/j.cell.2014.03.053

Figure 2. Rosetta Modeling of the GMPCPP Microtubule.

Figure 2

A) The low energy 1% GMPCPP ensemble is shown in cartoon representation, colored as in Fig. 1. Bound nucleotides are shown in stick representation and colored by heteroatom, as are magnesium ions (green) and coordinating water molecules. The map is displayed as a transparent grey isosurface. Regions of high-variability in the Rosetta ensemble (above an RMSF threshold of 0.89) are colored in shades of purple. B) β-tubulin C-terminal helices from the energy minimized consensus, all-atom Rosetta model, colored as in Fig. 1. Map is displayed as in A. C) Individual beta strands in the α-tubulin intermediate domain. (See also Tables S1b and S1c and Figures S3 and S4.)