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. Author manuscript; available in PMC: 2015 May 22.
Published in final edited form as: Cell. 2014 May 22;157(5):1117–1129. doi: 10.1016/j.cell.2014.03.053

Figure 5. Taxol binding restores the GDP lattice to a GMPCPP-like extended state.

Figure 5

A) Analogous to Fig. 2A, but comparing the GMPCPP (gold) to the GDP–taxol (light blue) state. B) View from the microtubule lumen of the superimposed GDP (light purple) and GDP–taxol (light blue) models. Note the swelling of the taxol binding site (1), opening of the E-site interface (2), and reversal of the longitudinal displacement of the α-tubulin intermediate domain (3). Nucleotides from the GDP-taxol consensus models are displayed and colored as in Fig. 3. Taxol is yellow. (See also Figure S6 and Movies S2 and S7)