Table 1.
Upregulated genes in DDT-resistant Benin population of Anopheles funestus after microarray
| Gene families | Gene name | Orthologs in Anopheles gambiae | Corrected P value | Fold-change | Log 2 fold-change | Description |
|---|---|---|---|---|---|---|
|
Glutathione S-transferases |
combined_c920 |
AGAP009194 |
0.0076 |
11.9 |
3.6 |
Glutathione S-transferase gste2 |
| combined_c920 |
AGAP009194 |
0.0047 |
8.8 |
3.1 |
Glutathione S-transferase gste2 |
|
|
Cytochrome P450s |
CYP6P9a |
AGAP002865 |
0.0091 |
6.4 |
2.7 |
Cytochrome P450 |
| |
CYP6P9b |
AGAP002865 |
0.0078 |
3.9 |
2.0 |
Cytochrome P450 |
|
Carboxylesterases |
gb-COEAE1G |
AGAP006700 |
0.0071 |
5.1 |
2.4 |
Alpha-esterase |
|
Short-chain dehydrogenases |
combined_c738 |
AGAP005166 |
0.0016 |
26.0 |
4.7 |
Short-chain dehydrogenase |
| |
AGAP008125-RA |
AGAP008125 |
0.0057 |
5.3 |
2.4 |
Short-chain dehydrogenase |
| |
AGAP001405-RA |
AGAP001405 |
0.0033 |
3.8 |
1.9 |
Short-chain dehydrogenase |
| |
combined_c1061 |
AGAP011852 |
0.0079 |
3.7 |
1.9 |
Short-chain dehydrogenase |
| |
AGAP001405-RA |
AGAP001405 |
0.0035 |
3.7 |
1.9 |
Short-chain dehydrogenase |
|
Cuticle proteins |
AGAP005999-RA |
AGAP005999 |
0.0048 |
10.8 |
3.4 |
Pupal cuticle |
| |
AGAP006867-RA |
AGAP006867 |
0.0034 |
5.2 |
2.4 |
Adult-specific cuticular protein acp-20 |
| |
AGAP010906-RA |
AGAP010906 |
0.0038 |
3.6 |
1.9 |
Cuticle protein |
| |
combined_c1722 |
AGAP010122 |
0.0061 |
5.0 |
2.3 |
Pupal cuticle protein |
| |
combined_c1722 |
AGAP010122 |
0.0031 |
4.8 |
2.3 |
Pupal cuticle protein |
| |
AGAP006867-RA |
AGAP006867 |
0.0037 |
2.9 |
1.5 |
Adult-specific cuticular protein acp-20 |
|
Odorant binding proteins |
AGAP001012-RA |
AGAP001012 |
0.0038 |
8.2 |
3.0 |
Candidate odorant receptor |
| |
combined_c1773 |
AGAP006368 |
0.0064 |
2.7 |
1.5 |
Odorant binding protein 4 |
| |
combined_c1773 |
AGAP006368 |
0.0072 |
2.7 |
1.4 |
Odorant binding protein 4 |
| |
AGAP009390-RA |
AGAP009390 |
0.0082 |
2.1 |
1.1 |
Olfactory receptor |
|
Proteases |
AGAP004857-RA |
AGAP004857 |
0.0036 |
5.2 |
2.4 |
Clip-domain serine proteinase |
| |
gb-SP8905 |
AGAP003640 |
0.0057 |
4.0 |
2.0 |
Prolylcarboxypeptidase |
| |
AGAP006674-RA |
AGAP006674 |
0.0059 |
3.4 |
1.8 |
Serine protease |
| |
combined_c1563 |
AGAP003581 |
0.0039 |
2.3 |
1.2 |
Chymotrypsin-like protein |
| |
AGAP004904-RA |
AGAP004904 |
0.0056 |
4.5 |
2.2 |
Catalase |
| |
CD578028.1 |
AGAP006485 |
0.0081 |
3.8 |
1.9 |
Serine threonine-protein kinase rio1 |
|
Transporters |
combined_c1762 |
AGAP006364 |
0.0094 |
2.8 |
1.5 |
ABC transporter |
| |
combined_c3512 |
AGAP006186 |
0.0039 |
2.2 |
1.1 |
Calcium-transporting ATPase |
| |
AGAP012626-RA |
AGAP012626 |
0.0047 |
6.9 |
2.8 |
Serotonin transporter |
|
Heat shock proteins |
combined_c4173 |
AGAP001424 |
0.0021 |
11.6 |
3.5 |
Glycoprotein 93 |
| |
combined_c4173 |
AGAP001424 |
0.0049 |
9.6 |
3.3 |
Glycoprotein 93 |
| |
AGAP002076-RA |
AGAP002076 |
0.0033 |
2.7 |
1.4 |
Heat shock protein cognate isoform a |
|
Salivary proteins |
EE589639.1 |
AGAP008281 |
0.0063 |
3.0 |
1.6 |
d7-related 1 protein |
| |
EE590018.1 |
AGAP008216 |
0.0022 |
2.2 |
1.1 |
gsg7 salivary protein |
| |
EE589541.1 |
AGAP008283 |
0.0086 |
2.1 |
1.1 |
d7-related 3 protein |
|
UDP (uridine diphosphate) glucosyltransferases |
combined_c1211 |
AGAP007920 |
0.0030 |
2.1 |
1.1 |
Glucosylglucuronosyltransferases |
|
Other functions |
combined_c1691 |
AGAP013141 |
0.0041 |
34.4 |
5.1 |
Mediator complex |
| |
AGAP003209-RA |
AGAP003209 |
0.0083 |
5.0 |
2.3 |
Sterol desaturase |
| |
combined_c3636 |
AGAP001423 |
0.0031 |
3.7 |
1.9 |
Bifunctional purine biosynthesis protein |
| |
combined_c3636 |
AGAP001423 |
0.0040 |
3.6 |
1.8 |
Bifunctional purine biosynthesis protein |
| |
combined_c8340 |
AGAP003581 |
0.0047 |
2.7 |
1.4 |
Sorbitol dehydrogenase |
| combined_c1577 | AGAP000523 | 0.0047 | 2.1 | 1.1 | ATP synthase lipid-binding mitochondrial precursor |