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. 2014 May 22;2014:406453. doi: 10.1155/2014/406453

Figure 1.

Figure 1

Oral administration of PG attenuated severity of arthritis in CII-immunized mice. (a) Percent incidence of arthritis, (b) clinical scores of arthritis, and (c) HE staining of ankle joints. Mice were immunized with CII as described in Section 2. From the day of the first CII immunization, mice were orally administered with PG (2 mg per mouse) once a day. Incidence and clinical scores of CIA were recorded between days 18 and 56. On day 56 of the first CII-immunization, joints were collected for histological analysis. Control, CII-PBS, and CII-PG indicate nonimmunized mice, CII-immunized mice administered with PBS, and CII-immunized mice administered with PG, respectively. Data are representative of 3 independent experiments (n = 2–4 mice per group). Single asterisk (P < 0.05) and double asterisk (P < 0.01) indicate significant difference between PG- and PBS-administered groups.