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Administration of PG reduced cytokine expression in joints of CII-immunized mice. The expression of IL-17A (a), IL-6 (b), IL-1β (c), and IFN-γ (d) in joints was determined by quantitative real-time RT-PCR. Control, CII-PBS, and CII-PG indicate nonimmunized mice, CII-immunized mice administered with PBS, and CII-immunized mice administered with PG, respectively. Single asterisk (P < 0.05) and double asterisk (P < 0.01) indicate that the value is significantly different.
