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. 2014 Jun 12;7:16. doi: 10.3389/fneng.2014.00016

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Copyright © 2014 Arcot Desai, Gutekunst, Potter and Gross.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Neuronal activation with several microelectrodes. (A) Representative horizontal section through the dorsal hippocampus of a rat implanted with a microelectrode array. The image shows two microelectrode sites (depicted with arrows) ending within the hippocampal pyramidal cell layer. The section is stained for c-fos (blue) and NeuN (pink). Scale bar: 100 μm. (B) Estimated neuronal activation in 50 μm brain sections with multiple unplated and sonicoplated microelectrodes (micro, smicro respectively) implanted in the hippocampal cell layer. The horizontal black dotted line shows the mean number of neurons activated by a single macroelectrode for comparison.