Table 2.
Association results for APOE ε2 / ε4 and SNPs in TOMM40
| SNP | Chrom | Position (BP) | Allele (Coded) | AD |
CAA-related ICH |
BD-p | ||
|---|---|---|---|---|---|---|---|---|
| OR (95 % CI OR) | p | OR (95 % CI OR) | P* | |||||
| APOE E4 | 19 | n/a | ε4 | 3.99 (2.41–7.29) | 3.20 × 10–9 | 3.08 (1.68–5.63) | 2.41 × 10–5 | >0.20 |
| APOE E2 | 19 | n/a | ε2 | 0.44 (0.22–0.89) | 0.024 | 2.89 (1.57–5.33) | 8.72 × 10–5 | <0.0001 |
| rs2075650 | 19 | 50087459 | G | 3.39 (2.40–4.80) | 5.17 × 10–9 | 0.98 (0.69–1.38) | >0.20 | <0.0001 |
| rs34404554 | 19 | 50087749 | G | 3.38 (2.39–4.78) | 6.11 × 10–9 | 1.05 (0.62–1.78) | >0.20 | <0.0001 |
| rs11556505 | 19 | 50087984 | T | 3.38 (2.39–4.78) | 6.34 × 10–9 | 1.06 (0.63–1.75) | >0.20 | <0.0001 |
| rs769449 | 19 | 50101842 | A | 3.59 (2.29–5.62) | 2.38 × 10–5 | 1.24 (0.60–2.58) | >0.20 | 0.0003 |
| rs12972156 | 19 | 50079299 | G | 2.86 (1.92–4.25) | 1.99 × 10–4 | 0.79 (0.43–1.46) | >0.20 | <0.0001 |
| rs12972970 | 19 | 50079436 | A | 2.99 (1.97–4.53) | 0.0002 | 0.86 (0.46–1.63) | >0.20 | <0.0001 |
| rs157582 | 19 | 50088059 | T | 3.02 (2.18–4.18) | 2.74 × 10–8 | 1.08 (0.61–1.90) | >0.20 | <0.0001 |
| rs184017 | 19 | 50086809 | G | 3.00 (2.16–4.15) | 3.87 × 10–8 | 1.08 (0.61–1.88) | >0.20 | <0.0001 |
| rs157581 | 19 | 50087554 | C | 2.82 (2.03–3.92) | 5.86 × 10–7 | 0.89 (0.50–1.57) | >0.20 | <0.0001 |
| rs283815 | 19 | 50082173 | G | 2.53 (1.67–3.83) | 0.010 | 0.91 (0.48–1.72) | >0.20 | <0.0001 |
| rs157580 | 19 | 50087106 | G | 0.48 (0.36–0.64) | 0.0006 | 0.83 (0.60–1.14) | >0.20 | 0.008 |
| rs439401 | 19 | 50106291 | T | 0.52 (0.39–0.69) | 0.005 | 0.86 (0.62–1.20) | >0.20 | 0.010 |
| rs34095326 | 19 | 50087684 | A | 2.79 (1.78–4.37) | 0.007 | 1.00 (0.56–1.80) | >0.20 | 0.001 |
| rs10119 | 19 | 50098513 | A | 2.72 (1.69–4.35) | 0.031 | 0.44 (0.14–1.38) | >0.20 | <0.0001 |
Results of multivariate logistic regression analyses of association of variants in TOMM40 and APOE with AD and CAA-related ICH. Reported p values are adjusted for 235 independent tests using Bonferroni correction. APOE SNPs were directly genotyped, while SNPs within TOMM40 are derived from genome-wide genotyping with imputation as described above. Only SNPs with adjusted p<0.05 in AD case–control analysis are reported. The rightmost column reports results of the heterogeneity of effects test (BD). Significant p values (after Bonferroni adjustment) are consistent with differences in genetic effects between AD and CAA
AD=Alzheimer's disease, BD=Breslow–Day test, BP=base pairs, CAA=cerebral amyloid angiopathy, Chrom=Chromosome, OR=odds ratio, 95 % CI=95 % confidence interval