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. 2014 Jan 30;5(1):19. doi: 10.1186/scrt408

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Copyright © 2014 Li et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Human glutathione S-transferase Mu 2 mesenchymal stem cells (hGSTM2-MSCs) suppressed renal inflammatory cell infiltration in mouse kidney. 129/svj mice with anti-glomerular basement membrane antibody-induced glomerulonephritis (anti-GBM-GN) were injected with hGSTM2-MSCs or pCDH-MSCs (vector control) for 21 days, and renal inflammatory cell infiltration was analyzed by immunohistochemical analysis staining with anti-Iba1 (macrophages) and anti-CD3 (T lymphocytes). (A, B) Anti-Iba1 staining for macrophage infiltration in (A) pCDH-MSC-treated and (B) hGSTM2-MSC-treated mice. (C) Quantitative analysis of Iba1-positive cells expressed as cell numbers per high power field (P<0.05). (D-E) Anti-CD3 staining for T lymphocyte infiltration in (D) pCDH-MSC-treated and (E) hGSTM2-MSC-treated mice. (F) Quantitative analysis of CD3-positive cells expressed as cell numbers per high power field (P<0.05). Original magnification ×400, scale bars = 50 μm.