Table 2.
Sampling time (h) | GSK933776 (n = 6/dose) | Baseline b | Postdosing | Change (%) | 95% CI |
---|---|---|---|---|---|
0 to 4 |
1 mg/kg |
363.4 ± 60.1 |
350.2 ± 61.7 |
−3.6 |
(−10.8 to 3.6) |
|
3 mg/kg |
479.2 ± 65.8 |
446.4 ± 70.8 |
−6.8 |
(−14.9 to 1.2) |
|
6 mg/kg |
502.7 ± 71.1 |
456.1 ± 88.9 |
−9.7 |
(−15.4 to −3.9) |
5 to 12 |
1 mg/kg |
363.4 ± 60.1 |
333.9 ± 52.1 |
−7.9 |
(−12.6 to −3.2) |
|
3 mg/kg |
479.2 ± 65.8 |
428.9 ± 77.1 |
−10.7 |
(−20.2 to −1.2) |
|
6 mg/kg |
502.7 ± 71.1 |
433.5 ± 85.1 |
−14.2 |
(−19.8 to −8.6) |
0 to 12 |
1 mg/kg |
363.4 ± 60.1 |
340.6 ± 55.7 |
−6.2 |
(−11.2 to −1.1) |
|
3 mg/kg |
479.2 ± 65.8 |
435.7 ± 74.4 |
−9.2 |
(−17.9 to −0.5) |
6 mg/kg | 502.7 ± 71.1 | 442.2 ± 86.4 | −12.5 | (−18.0 to −7.0) |
aCI: confidence interval. Results are reported as means ± standard deviations. b-6 to −1 hours predosing.