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. 2014 Jan 10;5(1):5. doi: 10.1186/scrt394

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Copyright © 2014 Nascimento et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Paracrine effect of UCX® in hypoxia-induced apoptosis of HL-1 cardiomyocytes. (A through E) UCX®-derived CMN or CMH protect HL-1 cardiomyocytes from apoptosis (induced by hypoxia during 48 hours), as shown by the detection of apoptotic cells by TUNEL assay. (F) The percentage of apoptotic cells increases when cells are subjected to hypoxia for 48 hours, both in serum-containing (31.93% ± 1.59%) and serum-free BM medium (47.73% ± 2.02%). Importantly, when media are supplemented with UCX® conditioned media, the percentage of apoptotic cells is significantly decreased (CMN – 24.77% ± 1.70%; CMH – 23.67% ± 1.95%). ***P < 0.0001, n = 4.

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