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. 2014 May 27;171(12):2993–3009. doi: 10.1111/bph.12680

Figure 8.

Figure 8

Schematic diagram illustrating the possible mechanisms responsible for CORM-2 effects on LPS-induced VCAM-1 expression in RASFs. LPS activates a TLR4/MyD88/TRAF6/c-Src pathway leading to enhance two distinct signalling cascades, including NIK/IKKα/β-dependent activation of NF-κB and MAPKs-dependent activation of AP-1 transcription factors in RASFs. CORM-released CO decreased inflammatory responses by interfering with activation of NF-κΒ and AP-1, and expression of VCAM-1 protein, thereby suppressing leukoyte adhesion to RASFs.