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Islet and re-aggregated cluster responses to Bay K 8644. (A) Rat islets exhibited a steady increase in insulin secretion in response to higher concentrations of Bay K 8644, until 10 μM. (B) Human native islets did not respond with an increase in insulin secretion to Bay K 8644. (C) Re-aggregated islet cell clusters had significant responses to 1 μM and all higher concentrations of Bay K 8644. *P < 0.05. **P < 0.01, significantly above baseline.
