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Islet and re-aggregated cluster responses to glibenclamide. (A) Native rat islets were exposed to increasing concentrations of glibenclamide with greater release of insulin. (B) Native human islets showed no response to glibenclamide. (C) Human re-aggregated clusters responded with increasing insulin secretion from 10 nM glibenclamide. *P < 0.05. **P < 0.01, significantly above baseline.
