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Islet and re-aggregated cluster responses to tolbutamide. (A) Native rat islets were exposed to increasing concentrations of tolbutamide with increased release of insulin at 10 μM tolbutamide and higher. (B) Native human islets showed no response to tolbutamide. (C) Human re-aggregated clusters responded with increasing insulin secretion from 3 μM tolbutamide. *P < 0.05. **P < 0.01, significantly above baseline.
