Table 4.
Quality of responses: Z-factor
| Native rat islets | Native human islets | Human re-aggregated clusters | |
|---|---|---|---|
| Bay K 8644 | −3.11 | −162.74 | −0.03 |
| Glibenclamide | −0.48 | −5.32 | 0.51* |
| Tolbutamide | −0.09 | −2.04 | 0.37* |
| Carbachol | −0.70 | −99.85 | −2.26 |
| Caffeine | −0.26 | −2.25 | −6.31 |
| α-Ketoisocaproic acid | −1.32 | – | 0.03 |
| GLP-1 | −0.56 | −8.01 | −2.91 |
| GRP | −9.88 | – | −15.19 |
| IBMX | −0.23 | −0.79 | −1.69 |
| Somatostatin | −1.50 | – | 0.54* |
| Nifedipine | −0.55 | −41.95 | −0.89 |
| Diazoxide | −0.35 | – | −1.45 |
| Sodium azide | −0.80 | – | 0.53* |
The statistical effect size was calculated as described by Iversen et al. (2004).
*
Z-factor score, indicating a positive response by the compound >0.4 is rated as excellent. Only the human re-aggregated islet clusters demonstrated any assays scoring in the excellent category.