Figure 2.

The effect of topiramate on the behavioural effects of cocaine. (A) A single dose of topiramate was administered either 120 min before the operant self-administration session or 120 min before the cocaine injection. Mean ± SEM operant responses for 10% v v⁻¹ ethanol was averaged over three days (n = 9–11 per group). ##P < 0.01 compared with the two cocaine-groups (20 mg·kg⁻¹). *P < 0.05 compared with the group treated with topiramate before cocaine injection. Only topiramate before ethanol was effective at reducing cocaine-induced responses to ethanol. (B) Motor activity. Mean ± SEM of the accumulated beam breaks for the 30 min after cocaine injection. Topiramate was administered 120 min before the cocaine injection. *P < 0.05 and ***P < 0.001 compared with the either the vehicle or the topiramate 40 mg·kg⁻¹ group.