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. 2014 May 27;171(12):3065–3076. doi: 10.1111/bph.12635

Figure 2.

Figure 2

Involvement of the V1A receptor in OT inhibition of ASIC currents. The current traces in A and B show that the inhibition of IpH 5.5 by OT (10−5 M) pre-applied alone was abolished by the co-application of OT and SR49059 (3 × 10−5 M), a selective V1A receptor antagonist, but not by addition of L-368899 (3 × 10−5 M), a non-peptide OT receptor antagonist. The current traces in (C) show that AVP has a similar inhibitory effect on IpH 5.5, and the inhibition was also blocked by SR49059. Bar graphs in the right panel show currents normalized to control (100%). Data in all bar graphs are shown relative to control. Error bars show ±SEM. Statistical tests were performed on raw data using paired t-test, and significance is shown as follows: *P < 0.05, **P < 0.01. n = 8 in each column.