Table 1.
Cytotoxicity (CC50: μg/mL), in vitro antiviral activity (IC50: μg/mL), and therapeutic index (TI) for each sample.
| Samples | CC50a | Treating before infection | Treating during infection | Treating after infection | |||
|---|---|---|---|---|---|---|---|
| IC50a | TI | IC50a | TI | IC50a | TI | ||
| TFE | 85 ± 1.7 | NA | NA | 41 ± 1.2 | 2.07 | 19 ± 1.6 | 4.47 |
| EAE | 60 ± 2.1 | NA | NA | 36 ± 1.9 | 1.67 | 16 ± 1.9 | 3.75 |
| Amentoflavone | 53 ± 0.9 | NA | NA | 52 ± 0.8 | 1.02 | 25 ± 1.2 | 2.12 |
| ACV | >500 | NA | NA | NA | NA | NA | NA |
CC50: the half of the cytotoxic concentration; IC50: the inhibitory concentration required to reduce viral replication by 50%; TI: the ratio of CC50/IC50; NA: no activity in the assayed concentrations; ACV: acyclovir; EAE: ethyl acetate extracts of S. moellendorffii; TFE: total flavonoid extracts of S. moellendorffii. aMean ± SD values are shown from three independent experiments.