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. 2014 Jun 15;25(12):1877–1891. doi: 10.1091/mbc.E13-10-0592

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© 2014 Renigunta et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 4: — Clathrin-mediated endocytosis of TASK-1. (A) The effects of stx8 on TASK-1 currents in Xenopus oocytes with and without coexpression of AP180C, a suppressor of clathrin-mediated endocytosis. (B) The effects of mutating the dileucine-based endocytosis signal in stx8, the tyrosine-based endocytosis signal in TASK-1, or both on the amplitude of TASK-1 currents. For each batch of oocytes the currents were normalized to the currents measured with TASK-1 (or the mutant TASK-1^Y300A) alone. (C) The effect of mutating the two endocytosis signals on the surface expression of HA-tagged TASK‑1 in Xenopus oocytes. The surface expression was measured using an antibody-based luminometric assay (Materials and Methods).