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. 2014 Jun 12;10(6):e1003659. doi: 10.1371/journal.pcbi.1003659

Figure 2. Protein abundance, variability and conservation associated with general cellular processes.

Figure 2

We investigated properties of proteins involved in ten Reactome top-level pathways (A): Cell cycle, DNA replication, and chromosome maintenance [DR], Extracellular matrix organization [MO], Gene expression and RNA processing [GE], Membrane trafficking [MT], Metabolism [MB], Signal transduction [ST], Apoptosis [AP], Developmental Biology [DB], Transmembrane transport of small molecules [TM], and Cell-Cell communication [CO]. Several pathways were significantly higher conserved (yellow letters) or showed a significant lower conservation (blue letters). Similarly, several pathways showed significantly higher protein abundance variability (large font size) or significantly lower variability (small font size). (B–D) shows the precise distributions for the different investigated protein features. Colored boxes indicate a significantly (p<0.01; Mann-Whitney-Wilcoxon test) lower (purple) or higher (red) abundance/variability/conservation of the proteins within the class as compared to proteins not in the class. The horizontal red line marks the median value for all proteins in Reactome.