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Effects of acetaminophen (APAP) treatment on nuclear condensation and DNA fragmentation. (A) Control (non-treated) and (B) APAP-treated Hep3B cells. Following cell treatment with APAP for 72 h, nuclear morphology was observed by nuclear staining with the Hoechst 33342 dye. Nuclear condensation (yellow arrows) and DNA fragmentation (white arrows) were observed on APAP-treated cells.
