Table 1.
Parameters | Baseline | I 30 min | R 30 min | R 60 min | R 90 min | R 120 min |
---|---|---|---|---|---|---|
LVSP (mmHg) | ||||||
Sham | 112.04 ± 4.14 | 112.38 ± 6.94 | 105.00 ± 10.49 | 102.73 ± 11.59 | 110.35 ± 6.59 | 102.69 ± 15.56 |
IR | 109.60 ± 8.79 | 96.16 ± 8.26 | 88.96 ± 5.55 | 89.00 ± 7.92 | 90.88 ± 9.97** | 93.84 ± 4.41 |
BA L | 111.83 ± 16.32 | 117.98 ± 17.12 | 110.28 ± 20.84 | 105.87 ± 26.25 | 107.31 ± 16.88 | 104.59 ± 18.16 |
BA M | 111.94 ± 12.05 | 121.68 ± 5.66 | 116.31 ± 16.24# | 118.04 ± 18.63# | 111.18 ± 21.05 | 97.89 ± 10.58 |
BA H | 119.00 ± 9.99 | 124.58 ± 9.48# | 116.89 ± 16.53# | 115.06 ± 11.78# | 115.18 ± 18.72 | 108.35 ± 21.23 |
Fos | 103.75 ± 18.86 | 111.85 ± 6.00 | 101.37 ± 22.47 | 105.61 ± 16.36 | 102.85 ± 20.80 | 97.17 ± 20.11 |
LVEDP (mmHg) | ||||||
Sham | 1.17 ± 5.06 | 6.83 ± 1.88 | 4.10 ± 3.69 | 1.13 ± 2.92 | 3.29 ± 6.03 | 6.76 ± 5.43 |
IR | 2.40 ± 0.67 | 41.09 ± 5.01*** | 34.56 ± 4.41*** | 31.89 ± 3.52*** | 28.08 ± 3.02*** | 22.65 ± 2.47*** |
BA L | −1.10 ± 1.88 | 15.35 ± 4.29### | 10.99 ± 2.73### | −0.97 ± 1.30### | 3.22 ± 1.51### | 3.73 ± 1.08### |
BA M | −0.12 ± 0.88 | 5.18 ± 0.99### | 7.95 ± 4.73### | −0.14 ± 1.54### | 3.52 ± 0.82### | −0.17 ± 0.55### |
BA H | 3.57 ± 0.79 | 1.44 ± 0.38### | 1.68 ± 0.63### | 0.96 ± 0.29### | 0.39 ± 1.84### | −3.85 ± 4.78### |
Fos | −1.36 ± 3.46 | 1.22 ± 4.72### | −1.89 ± 1.20### | −1.79 ± 0.74### | −1.78 ± 1.81### | −1.49 ± 2.36### |
+dp/dt max (mmHg/s) | ||||||
Sham | 2796.99 ± 747.48 | 2159.27 ± 616.19 | 2133.73 ± 664.39 | 1913.15 ± 746.26 | 1914.93 ± 740.10 | 2140.04 ± 904.89 |
IR | 2314.22 ± 523.11 | 1158.08 ± 126.28* | 1530.25 ± 457.50 | 1436.53 ± 335.40 | 1431.64 ± 396.76 | 1516.97 ± 301.25 |
BA L | 2622.34 ± 554.96 | 2567.47 ± 783.53## | 2966.97 ± 727.40## | 2862.31 ± 929.28## | 2780.30 ± 676.20## | 2669.20 ± 607.90# |
BA M | 2872.46 ± 900.11 | 3050.93 ± 530.30### | 3163.21 ± 549.83### | 2912.10 ± 761.54## | 2827.94 ± 631.95## | 2974.98 ± 607.48## |
BA H | 3084.91 ± 652.90 | 3340.11 ± 416.84### | 2952.91 ± 562.36## | 2992.94 ± 266.80### | 2982.98 ± 418.88### | 2860.16 ± 626.23## |
Fos | 2671.93 ± 811.72 | 2445.77 ± 495.77## | 2604.37 ± 1088.58# | 2459.49 ± 906.66 | 2440.16 ± 593.09 | 2425.22 ± 520.44 |
−dp/dt max (mmHg/s) | ||||||
Sham | 2538.50 ± 842.98 | 2088.54 ± 804.64 | 1667.45 ± 538.83 | 1255.24 ± 521.60 | 1621.34 ± 727.98 | 1804.14 ± 766.69 |
IR | 2470.82 ± 710.12 | 1851.84 ± 511.17 | 1724.73 ± 154.39 | 1263.52 ± 202.00 | 1137.58 ± 215.10 | 1670.25 ± 353.45 |
BA L | 3235.65 ± 907.33 | 2985.13 ± 649.47## | 2264.23 ± 654.76 | 2681.89 ± 918.39### | 2574.89 ± 615.74### | 2444.46 ± 570.20 |
BA M | 3716.18 ± 615.38## | 3155.59 ± 305.19### | 3020.08 ± 527.96## | 2455.59 ± 427.79## | 2321.44 ± 448.27## | 2809.39 ± 734.00## |
BA H | 3673.42 ± 396.67## | 3258.30 ± 416.35### | 2869.15 ± 466.16## | 2978.49 ± 297.56### | 2550.87 ± 756.55### | 2270.48 ± 612.49 |
Fos | 2864.85 ± 610.09 | 2390.76 ± 677.84 | 2391.93 ± 718.98 | 2564.15 ± 514.71## | 2346.04 ± 577.70## | 2247.83 ± 513.18 |
HR (beats/min) | ||||||
Sham | 392.58 ± 66.04 | 376.55 ± 35.80 | 370.02 ± 44.77 | 339.31 ± 42.13 | 332.37 ± 56.53 | 317.47 ± 72.61 |
IR | 406.84 ± 30.06 | 319.83 ± 70.13 | 324.68 ± 32.55 | 311.47 ± 38.66 | 289.73 ± 58.39 | 286.94 ± 49.31 |
BA L | 423.22 ± 33.79 | 389.34 ± 26.38# | 394.86 ± 15.99# | 370.48 ± 35.85 | 365.28 ± 26.74# | 343.66 ± 34.22 |
BA M | 421.08 ± 34.06 | 416.78 ± 15.23### | 391.48 ± 25.79 | 363.22 ± 26.80 | 357.79 ± 39.67 | 336.57 ± 42.96 |
BA H | 416.65 ± 35.79 | 411.22 ± 29.49## | 370.43 ± 25.76 | 366.98 ± 35.70 | 389.45 ± 50.12### | 380.80 ± 54.36## |
Fos | 393.02 ± 57.07 | 390.88 ± 40.24# | 338.62 ± 59.94 | 312.03 ± 67.08 | 328.87 ± 35.22 | 312.22 ± 57.54 |
LVSP: left ventricular systolic pressure; LVEDP: left ventricular end-diastolic pressure; ±dp/dt max: the rate in rise and fall of ventricular pressure; HR: heart rate. I: ischemia; R: reperfusion. All data were expressed as the mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001 versus Sham; # P < 0.05, ## P < 0.01, ### P < 0.001 versus IR.