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. 2014 Mar 28;9(6):2061–2068. doi: 10.3892/mmr.2014.2089

Figure 1.

Figure 1

Effect of sex hormones on renal function following IR injury. AKI was induced by bilateral renal ischemia for 23 min. Blood samples were collected 48 h after IR injury from the normal male mice (Con), normal male mice with AKI (AKI), castrated male mice with AKI (C+AKI), testosterone-replaced castrated male mice with AKI (CT+AKI), as well as normal female mice (Con), normal female mice with AKI (AKI), ovariectomized female mice with AKI (O+AKI), and estrogen-replaced ovariectomized female mice with AKI (OE+AKI). The BUN and creatinine levels from (A) male and (B) female mice were measured. Data are expressed as the mean ± standard deviation (n=10 mice per group). *P<0.05 vs. Con; †P<0.05 vs. AKI; #P<0.05 vs. castrated or ovariectomized AKI. BUN, blood urea nitrogen; IR, ischemia-reperfusion; AKI, acute kidney injury.