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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Hum Genet. 2014 Mar 4;133(7):905–918. doi: 10.1007/s00439-014-1431-7

Figure 7.

Figure 7

Summary of detected interaction models in the EA sample. GMDR-GPU (Zhu et al. 2013) was used to perform exhaustive searches for two- to five-way interaction models. The best interaction models for AD, CD, ND, and FTND shown in the figure were determined based on CVC >7 of 10 and prediction accuracy > 55%. The P value associated for each model shown here was < 0.005 based on 107 permutation tests. Interaction models with different phenotypes involved overlapped and highly correlated SNPs, which were grouped together. Group 3 includes rs1176758, rs3782025 and rs1672717; Group 4 includes rs9303628, rs140701 and rs2066713; Group 5 includes rs10789980, rs2276302 and rs897685. Pair-wise D values of adjacent SNPs within each group are greater than 0.7. SNP combinations are color-coded.