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. 2014 May 22;2014:193523. doi: 10.1155/2014/193523

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Copyright © 2014 Zhifeng Ning et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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PELP1 downregulation inhibited the CRC cell line HT-29 in vitro. (a) After transfection with shRNA, PELP1 protein expression was decreased by 90%. shRNA #3 was selected for further investigations. (b) After PELP1 silencing, the cell viability of HT-29 was inhibited. (c) PELP1 silencing inhibited the colony formation ability of HT-29 by 57.5% (lower panel). A representative colony formation assay is shown (upper panel). (d) PELP1 silencing inhibited the migration ability of HT-29 by 69.3% (lower panel). A representative migration assay is shown (upper panel). (e) PELP1 silencing inhibited the invasion ability of HT-29 by 58% (lower panel). A representative invasive assay is shown (upper panel). (f) Senescence was induced by PELP1 silencing in HT-29. A representative β-Gal assay is shown.