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. 2014 May 22;2014:193523. doi: 10.1155/2014/193523

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Copyright © 2014 Zhifeng Ning et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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PELP1 silencing suppressed CRC through c-Src downregulation. (a) PELP1 silencing was accompanied by the downregulation of c-Src mRNA as determined by quantitative RT-PCR. (b) PELP1 silencing was accompanied by c-Src protein downregulation as determined by western blot. (c) Decreased cell viability induced by PELP1 silencing was recovered by c-Src upregulation in HT-29. (d) Decreased colony formation ability was recovered by c-Src upregulation in HT-29. (e) Decreased migration ability was recovered by c-Src upregulation in HT-29. (f) Decreased invasion ability was recovered by c-Src upregulation in HT-29. (g) Induced senescence by PELP1 silencing was inhibited after c-Src upregulation.