TABLE 2.

Effects of Crizotinib on Calcium Homeostasis

Calcium ( mg/dL)	8.4–10.2	8.4–10.2	8.4–10.2	8.4–10.2	8.2–10.4	8.4–10.2	8.4–10.2
	7.6	8.0	10.0	7.9/8.8*	8.9	8.3	8.3
Albumin (g/dL)	3.5–5.0	3.5–5.0	3.5–5.0	3.5–5.0	3.5–5.2	3.5–5.2	3.5–5.2
	3.5	3.8	4.8	3.6/3.8	3.9	3.7	2.6
Corrected Ca (mg/dL)†	8.4–10.2	8.4–10.2	8.4–10.2	8.4–10.2	8.2–10.4	8.4–10.2	8.4–10.2
	8.0	8.2	9.4	8.2/9.0	9.0	8.5	9.4
Phosphate (mg/dL)	Not performed	2.5–4.4	2.5–4.4	2.5–4.4	Not performed	Not performed	Not performed
		3.1	3.2	2.4/2.9
PTH (pg/mL)	15–75	15–75	15–75	15–75	15–72	15–75	15–75
	125	102	34	58	37	69	51
25-OH vitamin D (ng/mL)	10–52	10–52	10–52	10–52	30–80	10–52	10–52
	23	27	29	25	24	42	24
1,25-di-OH vitamin D (pg/mL)	18–64	18–64	18–64	18–64	38–88		18–78
	32	40	98	33	82		14
24 h urine calcium excretion		100–300 mg/24 h
	Not performed	32	Not performed	Not performed	Not performed	Not performed	Not performed

^*Patient initially hypocalcemic with subsequent improvement on calcium supplementation when endocrine studies drawn.

^†Calcium levels were corrected to an albumin level of 4.0 g/dL.

Values in bold are outside of the reference range.

PTH indicates parathyroid hormone.