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. 2014 May 21;2014:375986. doi: 10.1155/2014/375986

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Copyright © 2014 Yongli Zhan et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

YQQRG alleviated kidney morphologic lesions in PAN rats. (a) Rat in PAN group exhibited glomerular hypertrophy on days 10 and 15; no other pathological lesions were seen (PAS, magnification ×400, scale bar = 50 μm). (b) Extension of tubules with protein casts; interstitial inflammatory cell infiltration was obvious in the PAN group on days 10 and 15. YQQRG attenuated such lesions (PAS, magnification ×400, scale bar = 50 μm). (c) Diffuse effacement of podocyte foot process, mitochondria swelling, and disarrangement of microfilaments of podocytes occurred on day 3 and worsened on day 10. However, there was a trend of spontaneous attenuation on day 15. YQQRG protected against podocyte injury (magnification ×10000, scale bar = 2 μm).