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. 2014 May 21;2014:375986. doi: 10.1155/2014/375986

Figure 4.

Figure 4

YQQRG downregulated nephrin, podocin, and CD2AP mRNA expression and restored their protein expression. Nephrin podocin and CD2AP mRNA expression was upregulated about 2-fold in PAN group compared with sham group on day 3 (a) and upregulated about 3-fold on days 10 and 15 (d and g). Treatment with YQQRG significantly inhibited the mRNA expression of these genes on days 10 and 15 (a, d, and g). Western blot revealed that compared with sham group, nephrin, podocin, and CD2AP expression in the PAN group was significantly decreased starting on day 3 (P < 0.05), and treatment with YQQRG restored podocin and nephrin expression on days 3, 10, and 15, however only on day 3 for CD2AP (P < 0.05) (b, c, e, f, h, i). (Compared with sham group: *P < 0.05, **P < 0.01, compared with PAN group: ▲ P < 0.05, ▲▲ P < 0.01.)