Table 2. The pharmacokinetic parameters of digoxin and ginsenoside Rb1, Rb2, Rc and Rd after multiple ig SLE and 150/kg GE in rats (n = 5).
| Ginsenosides | t1/2 (h) | Tmax (h) | Cmax (ng/mL) | AUCall (ng.h/mL) | AUCINF_obs (ng.h/mL) | Cl_F_obs (L/h) | MRTINF_obs (h) | |
| Control | Digoxin | 2.99±2.32 | 2.33±1.03 | 11.75±4.22 | 68.30±25.96 | 76.14±30.04 | 7.48±3.09 | 5.65±2.85 |
| Rb1 | 17.24±2.16 | 10.00±4.47 | 430.32±135.11 | 14066±5067 | 14324±5178 | 0.0079±0.0035 | 28.09±4.81 | |
| Rb2 | 20.15±3.66 | 12.00±0.00 | 512.33±77.75 | 15937±3310 | 16600±3511 | 0.0062±0.0013 | 29.50±2.61 | |
| Rc | 20.81±9.64 | 11.20±1.79 | 475.56±64.04 | 12569 ±1821 | 14462 ±2343 | 0.0143±0.0035 | 22.35±9.98 | |
| Rd | 20.81±9.64 | 8.00±2.45 | 261.64±103.87 | 6569±1821 | 7462±2343 | 0.0143±0.0035 | 22.35±9.98 | |
| SLE | Digoxin | 2.19±0.87 | 3.28±1.73 | 22.94±13.67* | 123.24±52.78* | 126.79±52.07* | 4.49±1.75* | 4.78±0.91 |
| Rb1 | 19.31±8.29 | 9.60±2.19 | 735.89±142.95 | 25644±1305** | 27017±2381** | 0.0037±0.0003 | 33.50±7.91 | |
| Rb2 | 24.28±8.42 | 10.00±2.83 | 585.87±95.24 | 21261±6522** | 22557±6121** | 0.0047±0.0011 | 26.51±6.58 | |
| Rc | 26.75±3.08 | 11.20±1.79 | 422.52±86.49 | 14641±2687 | 16729±8560 | 0.0028±0.0002 | 40.03±4.04 | |
| Rd | 17.97±75.93 | 8.00±2.45 | 264.68±49.43 | 7641±2687 | 11729±8560* | 0.0125±0.0084 | 26.32±90.58 |
In control group: rats were given the vehicle (0.5% sodium CMC) once a day for 10 continuous days. On the 11th day, digoxin (0.5 mg/kg) / GE (120 mg/kg) was administered intragastrically to rats. In SLE+GE group: rats were given a dose of SLE intragastrically at 500 mg/kg suspended in 0.5% sodium CMC once a day for 10 continuous days. On the 11th day, digoxin (0.5 mg/kg) / GE (120 mg/kg) was administered intragastrically to rats.
*:P<0.05 & **:P<0.01.