Table 4. Conditional Logistic Regression Analyses with Bonferroni Step-down Adjustment of Serum Biomarker Levels of AIDS-NHL and control subjects.
Biomarker | A-NHL (n = 46) | Controls (n = 46) | Exact p-value | Bonferroni Adjusted p-value | ||
Mean | SD | Mean | SD | |||
ApoA1 | 1267 | 252 | 1374 | 213 | 0.0111 | NS |
CA 19-9 | 4.97 | 26.9 | 0.490 | 0.197 | 0.0013 | NS |
CCL19/MIP-3β | 648 | 2777 | 196 | 77.5 | 0.0025 | NS |
CCL20/MIP-3α | 47.2 | 188 | 11.5 | 7.51 | 0.0056 | NS |
C3 | 111 | 47.3 | 81.9 | 30.3 | 0.0003 | NS |
CFH | 559 | 169 | 473 | 94.8 | 0.0016 | NS |
CXCL11/I-TAC | 436 | 535 | 175 | 151 | 0.0001 | 0.017 |
CXCL6/GCP-2 | 342 | 1362 | 114 | 51.7 | 0.0138 | NS |
CCL11 | 212 | 145 | 190 | 70.7 | 0.0061 | NS |
G-CSF | 176 | 325 | 73.8 | 71.9 | 0.0023 | NS |
HPN † | 5110 | 4037 | 3148 | 2284 | 0.0093 | NS |
I-309 | 11.3 | 29.9 | 3.39 | 3.52 | 0.0126 | NS |
IFNα | 13365 | 87796 | 65.5 | 189 | 0.0407 | NS |
IGFBP-3† | 1524 | 248 | 1420 | 328 | 0.0085 | NS |
IGFBP-5† | 120 | 72.6 | 90.8 | 58.3 | 0.0124 | NS |
IGFBP-6† | 149 | 42.0 | 169 | 64.0 | 0.0274 | NS |
IL-11 | 5663 | 36435 | 176 | 97.9 | <0.0001 | <0.017 |
IL-20 | 115 | 253 | 56.8 | 34.3 | 0.0177 | NS |
IL-28A | 555 | 3128 | 16.0 | 20.4 | 0.0249 | NS |
IL-29 | 11685 | 76491 | 232 | 127 | 0.0001 | 0.017 |
IL-7 | 49.7 | 146 | 18.4 | 7.37 | 0.0066 | NS |
IP-10 | 130 | 93.0 | 86.8 | 91.4 | 0.0173 | NS |
MCP-2 | 88.0 | 66.9 | 61.5 | 36.1 | 0.025 | NS |
M-CSF | 15887 | 105262 | 277 | 405 | 0.0065 | NS |
MIF | 964 | 2916 | 246 | 181 | 0.0402 | NS |
MIP-1δ | 5617 | 7942 | 3295 | 2265 | 0.0056 | NS |
MIP-4† | 22.2 | 19.4 | 16.0 | 7.88 | 0.0205 | NS |
MMP-3† | 57.5 | 163 | 18.1 | 7.30 | 0.0453 | NS |
MMP-9 † | 108 | 94.1 | 154 | 103 | 0.0171 | NS |
OC | 3996 | 2421 | 5375 | 3116 | 0.006 | NS |
PEDF† | 1777 | 424 | 1604 | 339 | 0.0379 | NS |
SAA † | 18574 | 67358 | 582 | 1020 | 0.0008 | NS |
SAP † | 4759 | 1623 | 3867 | 1307 | 0.004 | NS |
SCGF-B† | 60.3 | 49.4 | 45.9 | 15.7 | 0.0464 | NS |
sIL-1RI | 45.2 | 106 | 24.3 | 8.43 | 0.0041 | NS |
sTNF-RII† | 10.5 | 4.56 | 8.43 | 3.56 | 0.0172 | NS |
TIMP-1 † | 199 | 174 | 148 | 40.4 | 0.0096 | NS |
SD – standard deviation, NS - non-significant;
concentration expressed as ng/ml, all others expressed in pg/ml; Biomarkers in bold represent consensus markers also selected by non-parametric statistics.