Table 1. Effects of OAMB and 5-HT_1A knockdown in various assays.

Assays with adult flies	Effect		Likely effect on insulin signaling1 (output)		Different effects
	OAMB-Ri	5-HT1A-Ri	OAMB-Ri	5-HT1A-Ri
Starvation resistance	Increase	Decrease	Decrease	Increase	Yes*
Food intake (CAFE)	Increase	Decrease	Increase	Decrease	Yes*
Glucose (in circulation)	NE	Increase	NE	Decrease	Yes
Trehalose (in circulation)	NE	NE	NE	NE	No
Glycogen (stored)	NE	Increase	NE	Decrease	Yes
Trehalose (stored)	NE	Increase	NE	Decrease	Yes
Dilp2 transcript	NE	Up	NE	Increase	Yes
Dilp3 transcript	Up	NE	Increase	NE	Yes
Dilp5 transcript	NE	Up	NE	Increase	Yes
Oxidative stress resistance	Increase	Increase	Decrease	Decrease	No
IPC cell body size	NE	NE	NE	NE	No
Body weight	NE	NE	NE	NE	No

NOTES: ¹ This assumes that targeted receptor RNAi is similar to inactivating the receptor, which of course is not entirely correct. NE, no effect; * indicates opposite effect for the two knockdowns.