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. 2014 Jun 12;9(6):e99680. doi: 10.1371/journal.pone.0099680

Figure 4. KP supresses expression of MMPs and induces expression of TIMPs.

Figure 4

Trophoblast cells were either not treated (white bars) or treated with 100 nM KP (light grey bars), 1 µM KP antagonist (p356) (dark grey bars) or both treatments in combination (black bars) for 48 h. RNA was extracted and expression of MMP1 (A), MMP2 (B), MMP3 (C), MMP7 (D), MMP9 (E), MMP10 (F), MMP14 (G), MMP16 (H), TIMP1 (I), TIMP2 (J) and TIMP3 (K) was analyzed by qPCR. Error bars represent SEM. ANOVA test p<0.05, columns with different letters represent statistically different values, n.s.  =  no significant difference.